I just have enough USB to serial converter which will fail occasionally.
So , I decided to put aside some money to buy a PCI-e to RS232.
Once installed , the windows machine detected it accordingly.
which represented as COM5 and COM6.
Now to add this to VirtualBox, In setting just need to specify the host device as COM5 and mapped to virtual O/S serial.
and inside the box, we would be able to access as normal port. /dev/ttyS0 on CentOS 6.